IGFBP3 contributes to cell migration and proliferation in an endophytic tongue squamous cell carcinoma cell line. IGFBP3 contributes to cell migration and proliferation in an endophytic tongue squamous cell carcinoma cell line

We previously found that IGFBP3 mRNA levels are higher in endophytic-type human tongue squamous cell carcinoma (TSCC) that is more invasive and more prone to metastasis than exophytic and superficial types. To investigate the roles of IGFBP-3 in SAS cells that express a fluorescent ubiquitination-based cell-cycle indicator (Fucci). Overall design: SAS cells expressing Fucci were treated with siRNA for 48 and 72 h. The RNA was extracted from IGFBP3-knockdown and control cells for RNA-Seq.