Single cell transcriptome of dermal sheath cup cells contributing to efficacy of cell-based therapy for patterned hair loss

Autologous cell-based therapy using dermal sheath cup (DSC) cell is a new approach for male and female pattern hair loss. While its efficacy was recently reported, the mechanism of action remains unclear. Furthermore, the differences in treatment response require clarification. First, we used multivariate analysis to categorize two groups of individuals: patients in which therapy showed high efficacy (HE group) and patients in which therapy showed low efficacy (LE group). Then We analyzed the differences in gene expression between DSC cells from the HE and LE groups by single-cel transcriptome. Overall design: mRNA profiles of dermal sheath cup cells with high efficacy and low efficacy