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Single Cell RNAseq of Whole Lung Dissociates from IPF, COPD and control lungs Overall design: Exploratory analysis of disease and healthy lung cell populations
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2022-10-03
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Single-cell transcriptomics reveal cell type-specific molecular changes and altered intercellular communications in chronic obstructive pulmonary disease. Single-cell transcriptomics reveal cell type-specific molecular changes and altered intercellular communications in chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is a common and heterogeneous respiratory disease, the molecular complexity of which remains poorly understood, as well as the mechanisms by which aging an
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The human respiratory airways contain a distinct multipotent secretory cell lineage that can regenerate lung alveoli
The human lung differs substantially from its murine counterpart, resulting in a distinct distal airway architecture affected by disease pathology in chronic obstructive pulmonary disease. In humans,
NIAID Data Ecosystem10
Additional file 9 of Single-cell transcriptomics highlights immunological dysregulations of monocytes in the pathobiology of COPD
Additional file 9: Dataset 7. Genes dynamically expressed during AT2-to-AT1 differentiation, related to Fig. S4D and S4G, in which the top 500 genes based on wald statistics were differentiation drive
Figshare2022-12-20 更新10
Additional file 12 of Single-cell transcriptomics highlights immunological dysregulations of monocytes in the pathobiology of COPD
Additional file 12: Dataset 10. Lists for genes expressed in endothelial cells which are strongly correlated with genes from macrophages (Spearman correlation coefficient ≥ 0.8 or ≤ -0.8), related to
Figshare2024-02-07 更新20
Single-cell Transcriptome Analysis Reveals an Anomalous Epithelial Variation and Ectopic Inflammatory Response in Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a progressive disease that obstructs the airflow from the lungs, and tobacco smoking is the major cause of COPD. Here, we applied single-cell RNA sequen
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