Table 1_Modified Framingham stroke risk profile and related research on uric acid in individuals aged over 65 years in the Yangtze River Delta region, China.doc

BackgroundWith socioeconomic advancement stroke has garnered extensive public attention.
AimsThis study aimed to assess the 10-year risk of stroke among individuals aged over 65 years within a community utilizing the modified Framingham Stroke Profile (FSP). Additionally, the characteristics of high-risk factors for stroke and their associations with peripheral blood uric acid levels (UA) were explored.
MethodsA cross-sectional stratified survey method was employed, adhering to the principles of stratified sampling. Between February and October 2020, residents from seven community committees in the Suzhou High-tech Zone were selected to participate in questionnaire surveys and undergo blood biomarker testing to evaluate the 10-year stroke risk of stroke using the modified FSP.
ResultsAccording to the population-based modified FSP risk assessment, 823 individuals (51.0%) were classified as low risk, 703 individuals (43.6%) as medium risk, and 87 individuals (5.4%) as high risk. Peripheral blood uric acid levels were positively correlated with the 10-year stroke risk score (r = 0.135). Logistic regression analysis identified several risk factors for modified FSP medium-high risk in the community-dwelling population aged over 65 years, comprising male sex, age, hyperlipidemia, and hyperuricemia in Q4. Moreover, receiver operating characteristic (ROC) curve analysis identified peripheral blood uric acid level as a potential predictor of high stroke risk, with an area under the ROC curve (AUC) of 0.611 (medium+high vs. low). Lastly, the optimal diagnostic threshold was 292.5 μmol/L (approximately 4.92 mg/dL).
ConclusionThe stroke risk profile in this region warrants serious consideration. Elevated levels of uric acid (UA) are associated with increased modified FSP risk. Consequently, peripheral uric acid may serve as a limited indicator for discriminating medium-to-high modified FSP risk.