All vacccinated by years.

Introduction/objectivesThe effectiveness of vaccines depends not only on resource availability but also on broad public acceptance and the uptake of widely accessible vaccines. A vaccination campaign is a strategically coordinated initiative designed to enhance vaccine coverage within a specific population. This study evaluated the impact of health promotion strategies (HPS), including social marketing and education, on human papillomavirus (HPV) vaccine uptake among adolescents aged 9–19 years in City of Novi Sad, Serbia (population ~300,000). Since 2020, efforts have transitioned from individual to organized, publicly funded initiatives.Materials and methodsA descriptive epidemiological study was conducted using anonymized data from the electronic immunization registry (2019–2024). Data on HPS implementation were obtained from the Institute of Public Health of Vojvodina. Statistical analyses included Mann–Whitney U test, ANOVA, correlation, and multiple regression with time lag.Results and discussionFrom 2019 to 2024, 6,395 adolescents received the HPV vaccine, with sharp increases in 2023–2024. Among the different strategies analyzed, health promotion through educational media content delivered by physicians (TV, radio, social networks) and the implementation of the “Open Door” initiative had the most consistent and positive association with increased vaccination coverage. Vaccination uptake was strongly associated with frequent and accessible promotional activities, especially the “Open Door” initiative (r =.668, p ConclusionsAccessible, action-oriented interventions, particularly “Open Door” days, were the most effective strategy for increasing adolescent HPV vaccination. Social marketing combining convenience and multi-channel communication significantly enhanced uptake. These findings support the implementation of targeted, barrier-reducing public health strategies to improve vaccine coverage.