Light chain biases and kinetics following influenza virus infections in ferrets

The kinetic profile of the hemagglutinin-specific antibody responses were tracked for 72 days after a primary infection with an influenza A or B virus and 14 days after a secondary infection with H1N1 influenza A virus. The HA binding of the serum antibodies and the number of HA-specific antibody-secreting cells were tested at multiple timepoints post-infection. The HA-specific immunoglobulin lambda light chain and kappa light chain frequencies were observed. Specific dominant anti-HA Ig light chain frequencies expressed following influenza A primary versus secondary virus infection that result in specific antibody activity.