X-ray structure of human PPARalpha ligand binding domain-GW7647-SRC1 coactivator peptide co-crystals obtained by delipidation and co-crystallization

X-ray structure of human PPARalpha ligand binding domain-GW7647-SRC1 coactivator peptide co-crystals obtained by delipidation and co-crystallization Descriptor: 15-meric peptide from Nuclear receptor coactivator 1, 2-[(4-{2-[(4-cyclohexylbutyl)(cyclohexylcarbamoyl)amino]ethyl}phenyl)sulfanyl]-2-methylpropanoic acid, Peroxisome proliferator-activated receptor alpha Authors: Kamata, S, Ishikawa, R, Akahane, M, Oyama, T, Ishii, I. Deposit date: 2020-03-23 Release date: 2020-11-11 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.98 Å) Cite: PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020

通过去脂处理与共结晶技术获得的人类过氧化物酶体增殖物激活受体α（PPARα）配体结合域-GW7647-核受体辅激活因子1（SRC1）辅激活肽共晶体的X射线结构
描述信息：源自核受体辅激活因子1的15肽、2-[(4-{2-[(4-环己基丁基)(环己基甲酰基)氨基]乙基}苯基)硫基]-2-甲基丙酸、过氧化物酶体增殖物激活受体α
作者：Kamata S.、Ishikawa R.、Akahane M.、Oyama T.、Ishii I.
提交日期：2020-03-23
发布日期：2020-11-11
最后修订日期：2023-11-29
实验方法：X射线衍射（分辨率1.98埃）
引用文献：《含内源性脂肪酸与贝特类药物的PPARα配体结合域结构》，《Iscience》，第23卷，2020年