Maternal and fetal blood pharmacokinetics and organ distribution of atrazine, propazine, simazine and their metabolites in pregnant rats after chronic oral administration

Environmental contamination by chlorotriazines has been evidenced in mother-child cohort suggesting more detailed risk assessment of these compounds in drinking water. Exposure of rodents to atrazine has been associated to alterations of endocrine and reproductive functions by disrupting neuroendocrine control at hypothalamus level. Perinatal exposure to low doses of atrazine has been associated to reproductive dysfunction, and to behavioral abnormalities in adult exposed during embryogenesis. The objectives of the current investigation were to (1) evaluate the influence of physico-chemical properties of chlorotriazines on tissue distribution in pregnant rats and in fetuses, (2) gain a better understanding of fetal distribution of chlorotriazines in specific tissues, particularly in brain. Serial blood samples were obtained from pregnant rats after administration of atrazine (ATZ), propazine (PRO) and simazine (SIM) via oral route at a dose of 10 mg/kg from day 15 to day 19. Maternal an...母-婴队列研究已证实氯三嗪类（chlorotriazines）造成了环境污染，这提示需针对饮用水中的该类化合物开展更为细致的风险评估。啮齿动物暴露于阿特拉津（atrazine）后，可通过破坏下丘脑水平的神经内分泌调控，引发内分泌与生殖功能异常。围产期暴露于低剂量阿特拉津，不仅可引发生殖功能障碍，还会导致胚胎期暴露的成年个体出现行为异常。本研究的目标为：（1）评估氯三嗪类的理化性质对妊娠大鼠及胎鼠体内组织分布的影响；（2）进一步阐明氯三嗪类在特定组织（尤其是脑组织）中的胎体分布特征。 本研究通过灌胃途径给妊娠大鼠施以10 mg/kg剂量的阿特拉津（ATZ）、扑灭津（propazine，PRO）及西玛津（simazine，SIM），给药周期为妊娠第15天至第19天，并于给药后采集系列血液样本。母本的……