Binding sites of FOXG1 in human iPSC derived neural stem cells and 105 day old cerebral organoids

Derailed gene expression programs within the developing nervous system, encompassing both transcriptional and posttranscriptional processes, are implicated in diverse neurodevelopmental diseases. One of those debilitating diseases, the FOXG1-syndrome, lacks full understanding of the mechanistic role of its eponymous gene product, FOXG1. While it is known that FOXG1 acts in part at the chromatin by binding to regulative regions in the mouse, it is unclear which parts of the human chromatin associate with FOXG1. Here, we analyzed FOXG1 binding at the chromatin in human iPSC derived neural stem cells and 105 day old cortical organoids. Overall design: FOXG1-ChIPseq in human neural stem cell and cerebral organoids