KDM6A mutation in bladder cancer

NIAID Data Ecosystem2026-05-10 收录

膀胱癌KDM6A突变

表观遗传转录调控

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https://www.ncbi.nlm.nih.gov/sra/SRP506967 数据链接链接失效反馈

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KDM6A is one of the most frequently mutated chromatin modifier genes in bladder cancer. Here we investigate how this mutation affects the epigenetic and transcriptional landscape of bladder cancer.

创建时间：

2025-12-31

BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation

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BAP1去泛素化与基因激活

In Drosophila, a complex consisting of Calypso and ASX catalyzes H2A deubiquitination and has been reported to act as part of the Polycomb machinery in transcriptional silencing. The mammalian homolog

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Expression data from human cancer cells

癌细胞基因表达

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We used microarrays to profile gene expression of NCCIT cells to study the link between epigenetic modifications and gene transcription. Extract total RNA to examine gene expression of NCCIT cells in

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Data supporting figures for the manuscript : Interaction of Uteroplacental Insufficiency and Postnatal Western Diet on the Hepatic Transcriptome in Young Adult Female and Male Guinea Pigs .xlsx

发育起源肝代谢紊乱

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This study used a non-targeted transcriptomic analysis combined with miRNA-gene interaction prediction analysis, and subsequent chromatin immunoprecipitation assay and RT-PCR validation, and explored

Figshare2024-10-07 更新30

PRO-seq in control and H3.3 K4A mutant mESCs. PRO-seq in control and H3.3 K4A mutant mESCs

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干细胞分化

Study to investigate the role of histone residues H3K4 and H3K36 for gene expression, histone localization and neuronal lineage specification by mutation of K4 and K36 in H3.3 to alanine. Histone vari

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Next Generation Sequencing of sh-control and sh-KDM10A/KDM10B double knockdown HeLa Cells Transcriptomes. Next Generation Sequencing of sh-control and sh-KDM10A/KDM10B double knockdown HeLa Cells Transcriptomes

组蛋白甲基化功能

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Histone methyl groups can be removed by histone demethylases. Although LSD1 and JmjC domain-containing proteins have been identified to be histone demethylases, enzymes responsible for many histone me

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KDM6A mutation in bladder cancer

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