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Dual Roles of Methyl Ketones in Radziszewski-Type Reaction: Formal [2 + 1 + 1 + 1] Synthesis of 1,2,5-Trisubstituted Imidazoles

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NIAID Data Ecosystem2026-03-09 收录
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https://figshare.com/articles/dataset/Dual_Roles_of_Methyl_Ketones_in_Radziszewski_Type_Reaction_Formal_2_1_1_1_Synthesis_of_1_2_5_Trisubstituted_Imidazoles/3118075
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A highly efficient molecular iodine mediated Radziszewski-type reaction of methyl ketones, anilines, and tosylmethyl isocyanide has been developed. This protocol represents an elegant molecular fragment assembly of imidazoles via a formal [2 + 1 + 1 + 1] annulation. It is the first example where methyl ketones serve as the α-dicarbonyl compounds and aldehydes in Radziszewski-type reactions.
创建时间:
2016-03-28
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