Scavenger receptor A ameliorates acetaminophen induced hepatic inflammation

Acetaminophen-induced liver injury (AILI) occurs frequently and can be life threatening. Although AILI is mainly caused by the direct drug cytotoxicity, increasing evidence suggests that the interplay between hepatocytes and immune cells can define this pathogenic process. To further understand the immunoregulatory role of SRA in AILI, we performed RNA-sequencing analysis using hepatic nonparenchymal cells (NPCs) derived from acetaminophen treated WT or SRA-/- mice to demonstrate hepatocyte-extrinsic mechanisms governed by the immune receptor SRA that maintains liver homeostasis upon drug insult. Wild type and SRA-/- mice were injected with Acetaminophen (400 mg/kg). Six hours after acetaminophen injection, total RNA was extracted from hepatic non-parenchymal cells (NPCs) and subjected to RNA sequencing. RNA from Wild type cells are used as reference.