Expression profile of circular RNAs in oral lichen planus: a promising study of circRNA to explore the pathogenesis of oral lichen planus

Six oral mucous biopsies from untreated patients with oral lichen planus (OLP) and six normal oral mucous tissues from healthy patients were used for circRNA sequencing. 135 circRNAs with 2-fold differential expression were identified in OLP compared with normal control, including 83 upregulated circRNAs and 52 downregulated circRNAs. Ten selected circRNAs were validated by real-time qPCR Examination of different circular RNA expression in 2 tissue types. Control samples are identical to healthy oral mucosa samples in GSE131182.