Epigenome analysis of nodal marginal zone lymphoma and diffuse large b cell lymphoma. Epigenome analysis of nodal marginal zone lymphoma and diffuse large b cell lymphoma

Primary nodal marginal B cell lymphoma (nMZoL) is rare and is histologically very variable. Its distinction from nodal diffuse large B cell lymphoma (nDLBCL) is often difficult due to the absence of specific markers for marginal zone lymphomas in general. Using a comprehensive cohort of nMZoL and a control cohort of nDLBCL we conducted a methylome analysis on subgroups of both. Overall design: Bisulphite converted DNA from 35 nMZoL and 17 nDLBCL samples were amplified, fragmented and hybridised to Illumina Infinium MethylationEPIC BeadChip.