Analysis of murine implantation sites after exposure to soluble factors from HESCs.

Abnormal implantation sites were defined as those that had excessive focal bleeding, immune cell infiltration, obviously small for gestational age, or twin implantation. The incidence of abnormal implantation sites in the mouse uterus was significantly higher following exposure to soluble factors secreted by HESCs at D0 and D4 from RPL compared to control subjects. ***indicates P0.001;*indicates P0.05.