MTSS1 Suppresses Expansion and Activity of Mammary Tumor-initiating Cells by Mediating P65 Ubiquitination and Degradation

We conduct transcriptome comparison of control and Mtss1-overexpressed Py8119 cells to gain genomic insights on the biological processes that Mtss1 is involved in breast cancer cells. Through unsupervised cluster analysis of differentially expressed genes (DEGs), we found 1661 genes were significantly changed in Mtss1 cells. Single Site Analysis and Gene Set Enrichment Analysis show that Mtss1 downregualted numerous NF-?B targeted genes. Overall design: In the study presented here, Mtss1 was overexpressed in the Py8119 mouse breast cancer cells. RNA sequencing profiling of mRNA levels was performed in the control and overexpression cells.