Orthogonally Protected 1,2-Diols from Electron-Rich Alkenes Using Metal-Free Olefin <i>syn</i>-Dihydroxylation
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资源简介：
A new method for the stereoselective metal-free syn-dihydroxylation of electron-rich olefins is reported, involving reaction with TEMPO/IBX in trifluoroethanol (TFE) or hexafluoroisopropanol (HFIP) and the addition of a suitable nucleophile. Orthogonally protected syn 1,2-diols were obtained with high levels of diastereocontrol, and these products were selectively deprotected and selectively functionalized into synthetically useful compounds.
创建时间：
2016-11-14
