GCLC
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资源简介：
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]
谷氨酸-半胱氨酸连接酶，亦称γ-谷氨酰半胱氨酸合酶，是谷胱甘肽合成的限速酶。该酶由两个亚基组成，包括一个重催化亚基和一个轻调节亚基。此基因座编码催化亚基，而调节亚基则源自位于1p22-p21染色体上的另一个基因。该基因座的突变与γ-谷氨酰半胱氨酸合酶缺乏引起的溶血性贫血以及心肌梗死的易感性相关。[资料来源：RefSeq，2010年10月]
提供机构：
Rat Genome Database
