Crystal structure of the human METTL3-METTL14 complex bound to Compound 5 (ADO_AB_075)
收藏Protein Data Bank Japan2024-11-13 更新2026-04-19 收录
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Crystal structure of the human METTL3-METTL14 complex bound to Compound 5 (ADO_AB_075) Descriptor: 4-[[[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]amino]methyl]-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-4-ol, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... Authors: Bedi, R.K, Dolbois, A, Caflisch, A. Deposit date: 2021-03-25 Release date: 2021-09-01 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2 Å) Cite: 1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors. J.Med.Chem., 64, 2021
人源METTL3-METTL14复合物结合化合物5（ADO_AB_075）的晶体结构。描述符：4-[[[6-[(4,4-二甲基哌啶-1-基)甲基]吡啶-3-基]氨基]甲基]-1-[6-[(苄基)氨基]嘧啶-4-基]哌啶-4-醇、乙酸根离子、N6-腺苷甲基转移酶催化亚基……作者：Bedi, R.K.、Dolbois, A.、Caflisch, A.。提交日期：2021-03-25；发布日期：2021-09-01；最后修改日期：2024-11-13。实验方法：X射线衍射（分辨率2 Å）。引用：《1,4,9-三氮杂螺[5.5]十一烷-2-酮衍生物作为强效选择性METTL3抑制剂》，《J. Med. Chem.》，64卷，2021年。
创建时间：
2021-03-25
