Incidence of TB by country of origin - Estrie region

The identification and treatment of latent tuberculosis infection (LTBI) among immigrants from high-incidence regions who move to low-incidence countries is generally considered an ineffective strategy because only ≈14% of them comply with the multiple steps of the ‘cascade of care’ and complete treatment. In the Estrie region of Canada, a refugee clinic was opened in 2009. One of its goals is LTBI management. Between 2009-2020, 5131 refugees were evaluated. To determine the efficacy and benefit-cost ratio of this intervention, records of refugees seen in 2010-14 (n=1906) and 2018-19 (n=1638) were reviewed. Cases of tuberculosis (TB) among our foreign-born population occurring before (1997-2008) and after (2009-2020) setting up the clinic were identified. All costs associated with TB or LTBI were measured. Out of 441 patients offered LTBI treatment, 374 (85%) were compliant. Adding other losses, overall compliance was 69%. To prevent one case of TB, 95.1 individuals had to be screened a...对于从结核高流行地区移居至低流行国家的移民而言，潜伏性结核感染（latent tuberculosis infection, LTBI）的筛查与治疗通常被认为是效果不佳的干预策略，因为仅有约14%的受试者能够遵循“护理级联（cascade of care）”的多流程要求并完成全程治疗。加拿大埃斯特里（Estrie）地区于2009年开设了一家难民诊所，其核心目标之一即为潜伏性结核感染的管理工作。2009年至2020年间，该诊所共对5131名难民进行了评估。为评估该干预措施的有效性与成本效益比，研究人员回顾了2010-2014年（n=1906）及2018-2019年（n=1638）期间接诊的难民诊疗记录。研究人员还梳理了诊所开设前（1997-2008年）及开设后（2009-2020年）本地区境外出生人群的结核（tuberculosis, TB）发病案例，并对与结核或潜伏性结核感染相关的全部成本进行了核算。在441名接受潜伏性结核感染治疗的受试者中，374人（占比85%）依从了治疗方案；若计入其他类型的脱落情况，整体治疗依从率为69%。若要避免1例结核发病，需对95.1名个体进行筛查……