Regulation by LMP1 and LMP2A of EBV/HRS/IL-4 signature genes.

The EBV/HRS/IL-4 signature was defined as the 92 genes that were identified as common to the 2084 genes up-regulated in EBV-transformed LCLs established from GC-B cells [37], the 1747 genes up-regulated in HRS [38], and the 484 genes down-regulated by IL4 in T cells [35]. These 92 genes were then compared to those identified as up-regulated following expression of LMP1 or LMP2A in GC-B cells [41], [42]. All arrays were performed on the U133 plus2 Affymetrix array platform, where the probe-sets corresponded to 21014 annotated genes. The Gene Ontology function descriptions were obtained primarily from NCBI and AmiGO databases, assisted by manual literature search. Complete gene-lists are available in Data-File S2.