Research status of drug detection biomarker selection based on sewage epidemiology

In recent years, the trend of global drug abuse has become more popularized, entertainment-oriented, and younger, bringing unprecedented difficulties in discovery, detection and monitoring of drugs. Based on this, our country has established five centers in Zhejiang, Guangdong, and other places to out work based on sewage epidemiology and regional drug monitoring. By detecting regional sewage, we can timely discover drug abuse situations. Monitoring drugs in sewage urgently needs to the problem of biomarkers. It is necessary to choose precise and efficient biomarkers for detection within the range of drugs and their human metabolites, and to exclude influence of multiple factors, such as the stability of the target in sewage, the human metabolism rate, and interference from other sources. This paper analyzes and studies the common drug detection targets in domestic and international drug-related cases, determines their main metabolites and metabolic processes, analyzes and excludes the influencing factors of biomarker detection results, and provides detailed reference basis for the selection of drug detection targets in sewage.