Structure of the multidrug efflux pump EfpA from M. tuberculosis complexed with lipids

Structure of the multidrug efflux pump EfpA from M. tuberculosis complexed with lipids Descriptor: Uncharacterized MFS-type transporter EfpA, [(2~{R})-1-[(9~{Z},12~{Z},15~{E})-octadeca-9,12,15-trienoyl]oxy-3-phosphonooxy-propan-2-yl] nonadecanoate, [(2~{S})-1-dodecanoyloxy-3-phosphonooxy-propan-2-yl] tridecanoate Authors: Gao, F, Zhang, X, Li, D, Ma, X. Deposit date: 2023-11-22 Release date: 2024-11-27 Last modified: 2025-12-10 Method: ELECTRON MICROSCOPY (2.92 Å) Cite: Structure and function of Mycobacterium tuberculosis EfpA as a lipid transporter and its inhibition by BRD-8000.3. Proc.Natl.Acad.Sci.USA, 121, 2024结核分枝杆菌（M. tuberculosis）脂质结合型多药外排泵EfpA的结构 描述符：未表征的主要协同转运蛋白超家族（Major Facilitator Superfamily，简称MFS）型转运蛋白EfpA、[(2R)-1-[(9Z,12Z,15E)-十八碳-9,12,15-三烯酰氧基]-3-膦酰氧基丙-2-基]十九烷酸酯、[(2S)-1-十二烷酰氧基-3-膦酰氧基丙-2-基]十三烷酸酯 作者：Gao, F、Zhang, X、Li, D、Ma, X 提交日期：2023-11-22 发布日期：2024-11-27 最后修改日期：2025-12-10 解析方法：电子显微镜（分辨率2.92埃） 引用：结核分枝杆菌EfpA作为脂质转运蛋白的结构与功能及其被BRD-8000.3抑制的机制. 美国国家科学院院刊（Proc. Natl. Acad. Sci. USA）, 121, 2024