Differentially expressed genes and pathways in SARS-CoV-2 specific memory B cells across disease severity at single cell resolution

This dataset was generated as a part of a study where we looked at the gene signatures and pathways in RBD-specific memory B cells across disease severity in SARS-CoV-2 infected individuals at convalacense. We identified that certain activated memory B cell signatures that were maintained over a period of 6 months in severe infected individuals, whereas declined in mild/moderate over time.

本数据集源于一项研究，该研究针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染个体在恢复期的受体结合域（Receptor Binding Domain, RBD）特异性记忆B细胞中的基因特征与信号通路，按疾病严重程度展开分析。研究团队发现，重症感染者体内的部分活化记忆B细胞特征可维持6个月之久，而轻症/中症感染者体内的此类特征则随时间推移逐渐衰减。