The impact of different energy sources on redox balance during endometriotic cyst laparoscopy

Endometriosis is a common gynecological disorder seen in women worldwide.
It reduces fertility with significantly changes a woman's quality of
life. Laparoscopy proved to be standard treatment for endometriosis,
particularly for endometriomas. Disruption of oxidative stress balance has
been put in the focus in the recent studies. The aim of the study was to
follow the impact of cystectomy and compare bipolar and laser
electrocoagulation on prooxidative stress biomarkers and antioxidative
capacity. A total of 60 women with diagnosed endometriosis were included
in the study and divided in two groups according to laparoscopy treatment
with different energy sources for electrocoagulation. Prooxidative
parameters (superoxide anion radical (O2-), nitrites (NO2-), hydrogen
peroxide (H2O2), index of lipid peroxidation measured as TBARS) and
antioxidative defence system parameters (reduced glutathione (GSH),
activity of superoxide dismutase (SOD), activity of catalase (CAT)) were
determined spectrophotometrically before and after the surgery. The value
of H2O2 was decreased in group treated with biporal electrocoagulation,
while the value of GSH was increased in both groups. The value of O2- was
significantly decreased in the group treated with laser while SOD activity
was increased in the same group. The both methods had a similar effect on
index of lipid peroxidase and reduced glutathione, but when it comes to
the decreasing of harmful superoxide anion radical and increasing of SOD
activity, laser electrocoagulation showed better outcome. The role of
oxidative stress in both, understanding the pathogenesis of this disease
and as a potential therapeutic target, is certainly of great importance.