Background: Fucoidan (FPS) has been widely used to treat renal fibrosis (RF) in patients with diabetic kidney disease (DKD); however, the precise therapeutic mechanisms remain unclear. Recently, resea

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P20/P12 of caspase-11 mutant C254A

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caspase-11蛋白结构

P20/P12 of caspase-11 mutant C254A Descriptor: Caspase-4 Authors: Ding, J, Sun, Q. Deposit date: 2019-08-02 Release date: 2020-03-11 Last modified: 2025-03-12 Method: X-RAY DIFFRACTION (1.9 Å) Cite: S

Protein Data Bank Japan2025-03-12 更新30

Involution of Brown Adipose Tissue through a Syntaxin 4 Dependent Pyroptosis Pathway

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棕色脂肪代谢

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GSDME-mediated Pyroptosis Promotes Atherosclerosis

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动脉粥样硬化

Human atherosclerosis single-cell transcriptome analysis revealed that GSDME is mainly expressed in macrophages. In vitro, ox-LDL induces the expression of GSDME and pyroptosis in macrophages.

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CTRP3 mitigates sepsis-induced impairment of endothelial barrier function by suppressing pyroptosis in endothelial cells

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