Network Modelling using Transcription Sequence Data Reveals Novel MAPK Interactions Important for Drug Resistance. Aspergillus fumigatus

Caspofungin study on A. fumigatus. Applied to the Wild type as well as akuB, mpkA and sakA mutant. RNASeq-data Overall design: Samples were taken before treatment (0h) as well as 0.5h, 1h, 4h, 8h after treatment for the wild type and the akuB mutant. For the sakA and mpkA mutant, samples were taken at 0h, 1h and 4h after treatment.