Bcl-2 overexpression effects in rat neural precursor cells.. Bcl-2 overexpression effects in rat neural precursor cells.

Bcl-2 is highly enriched in the nervous system during neural development and plays an important role in modulating cell survival. In addition to its anti-apoptotic function, Bcl-2 has previously been suggested as a mediator of neuronal differentiation. However, the mechanism by which Bcl-2 might influence neurogenesis is not sufficiently understood. We aimed to determine the non-apoptotic functions of Bcl-2 during neuronal differentiation. Overall design: Two-condition experiments, Vector/-bFGF (Induction of neuronal differentiation) vs rBcl-2/+bFGF (Bcl-2 overexpression)