Acyl chain remodeling of DAG and TAG

Acyl chain remodeling of triacylglycerol (TAG) and diacylglycerol (DAG) progresses through their hydrolysis by patatin-like phospholipase domain-containing proteins 2/3 (PNPLA2/3). DAG is reacylated back to TAG by acylglycerol O-acyltransferase 1/2 (DGAT1/2), while DAG and its hydrolysis product 2-monoacylglycerol (2-MAG) are transacylated back to TAG by PNPLA2/3. In addition, the DAG hydrolysis product 2-MAG is subsequently hydrolyzed to fatty acid and glycerol by monoglyceride lipase (MGLL) (Jenkins et al. 2004).

三酰甘油（TAG）和二酰甘油（DAG）的酰基链重塑过程通过磷脂酶类似物结构域蛋白2/3（PNPLA2/3）的酯解作用进行。二酰甘油（DAG）通过酰基甘油O-酰基转移酶1/2（DGAT1/2）重新酰基化回TAG，同时，DAG及其水解产物2-单酰甘油（2-MAG）通过PNPLA2/3进行转酰基化回到TAG。此外，DAG水解产物2-MAG随后被单甘油酯脂肪酶（MGLL）水解成脂肪酸和甘油（Jenkins等，2004年）。