Safety and Biochemical Measurements at Baseline and Changes on Study.

Data are the mean (SD). All measurements were performed under fasting conditions. The significance of differences between treatment groups in the changes from baseline at weeks 2 and 14 was determined by unpaired t-tests, and differences that are statistically significant (P<0.05) are highlighted in bold. Asterisks (*) are used to indicate within-group changes from baseline that are statistically significant by paired t-test (P<0.05). Abbreviations: HOMA-IR: Homeostasis model assessment of insulin resistance (20). To convert to SI units: creatine µg/mL to µmol/L multiply by 7.625; creatinine mg/dL to µmol/L multiply by 88.4; triglycerides mg/dL to mmol/L multiply by 0.01129; cholesterol mg/dL to mmol/L multiply by 0.02586; glucose mg/dL to mmol/L multiply by 0.05551; insulin µIU/mL to pmol/L multiply by 7.175.