Replication Data for: Revisiting the effect of GnRH analogue treatment on bone mineral density in young adolescents with gender dysphoria

This letter analyses individual data on 24 patients from Joseph et al. (2019)’s sample of 31. It finds that after two years of GnRHa, up to a third of patients had abnormally low bone density, in the lowest 2.3% of the distribution for their sex and age. A few patients recorded extremely low values, in the lowest 0.13% of the distribution. This finding undermines Joseph et al.’s conclusions.本研究快报分析了取自Joseph等人2019年研究中包含31例受试者的样本的24名患者个体数据。研究发现，在接受为期两年的促性腺激素释放激素激动剂（GnRHa）治疗后，多达三分之一的患者出现骨密度异常降低，其骨密度值处于对应性别与年龄群体参考分布的最低2.3%分位区间内；少数患者的骨密度检测值极低，处于对应参考分布的最低0.13%分位区间内。该研究发现动摇了Joseph等人的研究结论。