MKN-45 cells were treated with PBS, BF-TK, BF/GCV or BF-TK/GCV for 48 h (GCV, 167 µg/ml), respectively. BF-TK (n = 3), BF/GCV (n = 3) or BF-TK/GCV (n = 3) groups were analyzed in triplicate.
Ring opening of 4-aryl-2-phenyloxazol-5-one 1 with 2-aminobenzoic acid in acetic acid and n -butanol gave compounds 2 and 3 , respectively. The 4 H -3,1-benzoxazin-4-one
The IC50 of these compounds are significantly different (p<0.05) from each other in different magnitude (nM vs µM); while compounds with the same magnitude (nM vs nM and µM vs µM) are not significantl
