Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium abscessus ATCC 19977 / DSM 44196 with NADP and inhibitor P218
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Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium abscessus ATCC 19977 / DSM 44196 with NADP and inhibitor P218 Descriptor: 1,2-ETHANEDIOL, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, CALCIUM ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID), Abendroth, J, Santhakumar, V, Walpole, C, Lorimer, D.D, Horanyi, P.S, Edwards, T.E. Deposit date: 2020-09-19 Release date: 2021-03-17 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Rational Exploration of 2,4-Diaminopyrimidines as DHFR Inhibitors Active against Mycobacterium abscessus and Mycobacterium avium , Two Emerging Human Pathogens. J.Med.Chem., 2024
脓肿分枝杆菌（Mycobacterium abscessus）ATCC 19977/DSM 44196来源的二氢叶酸还原酶（Dihydrofolate reductase, DHFR）结合烟酰胺腺嘌呤二核苷酸磷酸（NADP）与抑制剂P218的晶体结构
描述物：1,2-乙二醇、3-(2-{3-[(2,4-二氨基-6-乙基嘧啶-5-基)氧基]丙氧基}苯基)丙酸、钙离子……
作者：西雅图传染病结构基因组学中心（Seattle Structural Genomics Center for Infectious Disease, SSGCID）、Abendroth J、Santhakumar V、Walpole C、Lorimer D.D.、Horanyi P.S.、Edwards T.E.
保藏日期：2020-09-19
发布日期：2021-03-17
最后修改日期：2024-11-13
实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2 Å）
引用文献：《2,4-二氨基嘧啶类作为针对脓肿分枝杆菌与鸟分枝杆菌这两种新发人类致病菌的二氢叶酸还原酶抑制剂的理性探索》，《J.Med.Chem.》，2024年
创建时间：
2020-09-19
