Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis (AURORA-Metastatic-Breast-Multiomics)

The AURORA US Metastatic Breast Cancer project is funded by the Breast Cancer Research Foundation (BCRF) Evelyn H. Lauder Founder's Fund for Metastatic Breast Cancer Research. This multi-center effort was conducted within the Translational Breast Cancer Research Consortium (TBCRC) and cancer researchers to better understand the metastatic process through the study of both the primary and metastatic tissue. In the retrospective phase, 55 patients with 31 primary tissues and 102 metastases were profiled using whole genome DNA sequencing, whole exome DNA sequencing, DNA methylation arrays, and RNA sequencing. The related molecular data are hosted in dbGaP and GEO

H&E slides are available for 184 specimens (17 samples have 2 images, 12 have 3 images). H&E were performed on 53 primary breast cancer tissues, 99 metastatic samples, and 32 adjacent normal tissues. HLA-A immunofluorescence was performed on 37 samples.