Identified T-cell epitopes in wheat gluten and their observed T-cell response in celiac disease patients.

Glutamine residues expected to be targeted by TG2 are given in bold.aPeptide PQPQLPYPQPQLPY harboring both epitopes, DQ2-α-II and DQ2-α-III, was tested.bPeptide LQPQQPFPQQPQQPYPQQPQ harboring both epitopes, DQ2-γ-III/DQ8-γ-I and DQ2-γ-VI, was tested.cNote that this peptide is not identical to peptide QQPPFSQQQQQPLPQ which was previously known as the “Glt-17” epitope. Peptide QQPPFSQQQQQPLPQ has previously been tested for T-cell response in CD patients: 3/20 [17].♦Identified TG2 peptide substrates that harbor incomplete 9mer core binding regions.