Mammalian toxicokinetic database (MamTKDB) 1.0

Elimination half-lives in mammals, including humans, have been proposed as a potential complementary metric to expand the assessment of bioaccumulative properties of a substance to cover air-breathing organisms. In order to explore the possibilities of using such data in bioaccumulation assessment and predictions, human and terrestrial mammalian elimination half-life data have been collected along with physiochemical data/parameters. The database will facilitate looking up toxicokinetic data and finding respective studies. This first version of the Mammalian toxicokinetic database (MamTKDB 1.0) contains elimination half-life values for around 1400 substances collected from publications and publicly available studies. The data were collected by Norwegian Institute of Public Health (NIPH) together with European Chemicals Agency (ECHA) in 2016-2020 (Hofer T, Peltola-Thies J, Karamertzanis P, Myhre O, Lantto T, Hirmann D).包括人类在内的哺乳动物的消除半衰期（elimination half-life）已被提议作为潜在补充指标，以将物质生物累积性评估的覆盖范围拓展至空气呼吸生物。为探索此类数据在生物累积性评估与预测中的应用潜力，研究团队已收集人类及陆地哺乳动物的消除半衰期数据，并同步收录相关理化数据与参数。本数据库可为毒代动力学（toxicokinetic）数据查询及对应研究文献的检索提供便利。本哺乳动物毒代动力学数据库（MamTKDB 1.0）的首个版本，共收录约1400种物质的消除半衰期数值，所有数据均来自已发表文献及公开研究成果。该数据集于2016年至2020年间由挪威公共卫生研究所（Norwegian Institute of Public Health, NIPH）与欧洲化学品管理局（European Chemicals Agency, ECHA）联合收集（参考文献：Hofer T, Peltola-Thies J, Karamertzanis P, Myhre O, Lantto T, Hirmann D）。

搜集汇总

背景与挑战

背景概述

MamTKDB 1.0是一个由欧洲化学品管理局发布的毒代动力学数据库，专注于收集哺乳动物（包括人类）的消除半衰期数据，用于评估化学物质的生物累积性。该数据库包含约1400种物质的数据，来源于公开出版物和研究，数据格式为Excel XLSX，公开可访问。