Differential chromatin landscape in myxoid liposarcoma and Ewing sarcoma

A subgroup of sarcomas and leukemias is defined by characteristic FET (FUS, EWSR1, TAF15) fusion oncogenes. Myxoid liposarcoma (MLS) and Ewing sarcoma (EWS) are the most common entities characterized by the fusion oncogenes FUS-DDIT3 and EWSR1-FLI1, respectively. Here, we performed ATAC-Seq on the cell lines MLS 1765-92 and EWS TC-71 to characterize and compare their chromatin landscape. Overall design: ATAC-Seq was performed on the myxoid liposarcoma cell line MLS 1765-91 and the Ewing sarcoma cell line EWS TC-71 (n=3) to compare chromatin accessibility patterns.