Biodistribution of liposomes following CED to F98 glioma bearing rats.
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aF98 glioma cells were implanted into the right caudate nucleus of 8 Fischer rats. Twelve to 14 d later, they received CED of cisplatin containing CHEMS liposomes (9.6 µg in 10 µl over 30 min) and were euthanized either immediately following (t = 0 h.) CED or 24 h later. The tumors, BAT and normal brain and blood samples were collected and Pt concentrations were determined by ICP-OES.bBrain around tumor arbitrarily included an area of 1 mm beyond the dissected margins of the tumor.cMeans and standard deviations (SD) were calculated on values obtained from 4 rats for each time point.dThe P-value
创建时间：
2015-12-02
