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Metabolic and transcriptional changes following two, four and six weeks following TAC and Sham Surgery

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Eight-week-old male mice (C57BL/6N) were randomly subjected to isolated thoracotomy (ITH) or transaortic banding (TAC). Healthy littermates were used as controls. Mice were sacrificed after 2 weeks, 4 weeks , and 6 weeks. All mice were assessed by echocardiography. Animals were fed ad libitum with Rod 16-A (LASvendi) and housed in a specific pathogen free environment as previously described. Microarray and metabolic panales were performed for all animals.

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