Expression data from upper and lower ileum of mice administered lactic acid bacteria, Lactococcus lactis C59 and Lactobacillus rhamnosus GG

This study aimed to investigate the effects of oral administration of lactic acid bacteria (LAB) on gene expression in murine ileum. Two LAB strains, Lactococcus lactis subsp. lactis C59 and Lactobacillus rhamnosus GG, were administered to mice for 2 weeks. Microarray analysis was performed using total RNA from upper and lower ileum to detail the gene expression of 3 groups; control, C59-administered and GG-administered. Gene expression of upper ileum was less affected by administered strains than that of lower ileum and the latter was strain-specifically affected. Balb/c mice (male, 7 week-old, n=6) in each group received 0.2ml (1 x 109 cells) of strain C59 or strain GG suspension for 2 weeks.