Gene Regulatory Subtype-specific Network of TCGA-STAD

These were the subtype-specific subnetworks in TCGA-STAD, which was identified with our proposed method[1] from the edge contribution value (ECv) [2]. Edges and nodes were colored by each subtype: subtype 1 (gray), subtype 2 (magenta), and subtype 3 (green). Colored nodes were hub nodes in each subtype and the color gradient represents the outdegree of hubs. The subtypes showed more clinically meaningful than the existing subtypes. This network was extracted from Gene Regulatory Basal Network of TCGA-STAD, which was generated from TCGA RNA-seq data for stomach adenocarcinoma (STAD) using Bayesian network estimation [3].