Crystal structure of PKC alpha in complex with NVP-AEB071

Crystal structure of PKC alpha in complex with NVP-AEB071 Descriptor: 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]-1H-pyrrole-2,5-dione, Protein kinase C alpha type Authors: Stark, W, Rummel, G, Strauss, A, Cowan-Jacob, S.W. Deposit date: 2009-09-02 Release date: 2009-11-03 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes J.Med.Chem., 52, 2009与NVP-AEB071结合的α型蛋白激酶C（PKC alpha）晶体结构 描述符：3-(1H-吲哚-3-基)-4-[2-(4-甲基哌嗪-1-基)喹唑啉-4-基]-1H-吡咯-2,5-二酮，α型蛋白激酶C 作者：Stark, W、Rummel, G、Strauss, A、Cowan-Jacob, S.W. 提交日期：2009-09-02 发布日期：2009-11-03 最后修改日期：2024-11-20 实验方法：X射线衍射（2.8 Å） 引用：《强效选择性蛋白激酶C同工型抑制剂3-(1H-吲哚-3-基)-4-[2-(4-甲基哌嗪-1-基)喹唑啉-4-基]吡咯-2,5-二酮（AEB071）的发现》，J.Med.Chem., 52, 2009