LSD1-CoREST in complex with T16, long soaking

LSD1-CoREST in complex with T16, long soaking Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(1R,3S,3aS,13R)-1-hydroxy-10,11-dimethyl-3-[3-(methylcarbamoyl)phenyl]-4,6-dioxo-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]pentyl dihydrogen diphosphate (non-preferred name) Authors: Caroli, J, Mattevi, A. Deposit date: 2023-10-16 Release date: 2025-02-05 Last modified: 2025-08-20 Method: X-RAY DIFFRACTION (2.74 Å) Cite: Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance. Nat Commun, 16, 2025与T16结合的LSD1-CoREST复合物（长时浸泡实验） 描述信息：赖氨酸特异性组蛋白去甲基化酶1A（Lysine-specific histone demethylase 1A）、REST共阻遏蛋白1（REST corepressor 1）、[(2R,3S,4R,5R)-5-(6-氨基-9H-嘌呤-9-基)-3,4-二羟基氧杂环戊烷-2-基]甲基 (2R,3S,4S)-2,3,4-三羟基-5-[(1R,3S,3aS,13R)-1-羟基-10,11-二甲基-3-[3-(甲基甲酰胺基)苯基]-4,6-二氧代-2,3,5,6-四氢-1H-苯并[g]吡咯并[2,1-e]蝶啶-8(4H)-基]戊基二氢二磷酸酯（非优选名称） 作者：Caroli, J、Mattevi, A. 提交日期：2023-10-16 发布日期：2025-02-05 最后修改日期：2025-08-20 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.74埃 引用文献：《共价加合物的Grob碎裂揭示LSD1去甲基化酶特异性抑制剂的作用机制与耐药性》，《自然·通讯》（Nat Commun），2025年，第16卷