Expression data from control or Hnf6/Oc2 compound mutant mouse embryonic spinal cords. Expression data from control or Hnf6/Oc2 compound mutant mouse embryonic spinal cords

In the embryonic spinal cord, cardinal populations of interneurons (INs) diversify into specialized subsets and migrate to defined locations within the spinal parenchyma.However, the factors that control IN diversification and migration remain almost totally unknown. We demonstrate with that Onecut proteins regulate the diversification and the migration of V2 INs in the spinal parenchyma. To identify genes downstream of Onecut transcription factors that may contribute to V2 interneuron differentiation and distribution, we performed a microarray comparison of control and of OC-deficient spinal cord transcriptome at e11.5, namely at the stage when significant numbers of V2 cells have been generated and are initiating migration Overall design: 5 controls and 5 Hnf6/Oc2 compound mutant mouse embryos