Additional file 5: Table S4. of Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation

GSEA bioinformatics assessment—ranked pathways by age. Ranked pathway dysregulations are shown separately on different datasheets for the predefined Reactome and KEGG gene sets regarding down- and upregulations, and progressive ages. Green background colors for the nominal p value and the False Discovery Rate q values indicate significance according to GSEA recommendations. Neuroinflammation pathways are highlighted in red color, MAPK signaling in purple, Parkinson’s disease in yellow, ubiquitination pathways in blue, endoplasmic reticulum stress response pathways in orange, the mTOR signaling pathway (mimicked by starvation stress during in vitro experiments) in dark gray, the vesicular pathways in light brown. (XLSX 123 kb)