Data from: Plasma dipeptidyl peptidase IV activity and measures of body composition in apparently healthy people

Aim: Based on its regulatory action on glucagon-like peptide 1, dipeptidyl
peptidase IV (DPP-IV) has increasingly been linked to Type 2 diabetes.
However, there is no evidence as to how this normal modulatory enzyme
leads to pathology. It is thought that DPP-IV is affected by the
development of obesity, which is a common precursor to Type 2 diabetes.
Little is known about the relationship between DPP-IV activity in plasma
and specific body composition measures. Main methods: In the current
study, plasma DPP-IV activity and body composition measures were collected
from 111 healthy subjects between the ages of 19 and 70 years old for
analysis. Key findings: The mean plasma DPP-IV activity was 35.9U/L ±
12.3, falling within normal reference value range presented by Durinx et
al. DPP-IV activity was negatively correlated with absolute body fat mass,
but absolute lean mass was positively correlated. Consistent with the
findings, DPP-IV activity was also negatively correlated with absolute
gynoid fat (p = 0.0047). DPP-IV activity did not have a significant
correlation with absolute android fat mass, visceral adipose tissue, BMI,
and age. Significance: From these results, it can be concluded that high
activity of DPP-IV is not indicative of pathology, and specific body
composition components may influence soluble DPP-IV activity in the blood.