Supplementary Material for: An intrauterine case of explosive growth of neurofibromatosis during pregnancy with fetal death in mid-pregnancy: A Case Report

INTRODUCTION: Neurofibromatosis type 1 (NF1) is one of the most prevalent autosomal dominant inherited diseases, with an incidence rate of 1/3000. The hallmark clinical features of NF1 include coffee milk spots (CALMs), multiple neurofibromas, and freckles in the armpit or groin. Numerous studies have indicated a higher incidence of pregnancy-related complications in patients with NF1, including fetal growth restriction and preeclampsia.CASE PRESENTATION: This case study describes a pregnant woman with NF1 who unfortunately experienced intrauterine fetal death during her second trimester and developed preeclampsia and HELLP syndrome. CONCLUSION: This case highlights the need for close monitoring and management of patients with NF1 during pregnancy and the critical role of multidisciplinary collaboration and follow-up of MDT.