Neural Inertia In Wild Type Mice.

Within the shaded area, subjects will be awake or anesthetized depending upon their previous state of arousal. This area represents a resistance to change in arousal state and graphically depicts neural inertia. (A) Halothane dose-response curve in wild-type mice for induction and emergence. (B) Isoflurane dose-response in wild-type mice. (C) One-way ANOVA with post-test Bonferroni multiple comparisons correction indicates that the residual volatile anesthetic in mouse brain at the corresponding EC50 for emergence is always significantly less than that at the EC50 for induction. **p<0.01. (D) Neural inertia in wild-type mice exposed to halothane (red) or isoflurane (purple). X-axis in A and B corresponds to the log of the inhaled anesthetic concentration. All neural inertia bar graphs carry units of log[Anesthetic (%atm)]. Filled squares and solid curve denote induction. Open squares and dashed curve denote emergence.