Straightforward Enantioselective Access to γ‑Butyrolactones Bearing an All-Carbon β‑Quaternary Stereocenter
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https://figshare.com/articles/dataset/Straightforward_Enantioselective_Access_to_Butyrolactones_Bearing_an_All_Carbon_Quaternary_Stereocenter/2253616
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资源简介：
An
enantioselective one-pot aldol/lactonization sequence has been
developed to access highly challenging γ-butyrolactones bearing
an all-carbon quaternary stereocenter at the β-position by reacting
acylated succinic esters with aqueous formaldehyde in the presence
of 3 mol % loading of a cinchona alkaloid-derived squaramide providing
direct access to paraconic acid derivatives in high yield and fairly
good level of enantioselectivity (up to 88% ee).
创建时间：
2014-09-19
