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Mycobacterium tuberculosis RNA polymerase elongation complex bound to inhibitor N-aroyl-N-aryl-phenylalanine amide (AAP)-SO2

NIAID Data Ecosystem2026-05-10 收录

结核分枝杆菌药物靶点

RNA聚合酶抑制剂

数据链接：

https://www.rcsb.org/structure/9MRQ 数据链接链接失效反馈

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资源简介：

Mycobacterium tuberculosis RNA polymerase elongation complex bound to inhibitor N-aroyl-N-aryl-phenylalanine amide (AAP)-SO2

应用场景：

创建时间：

2025-10-08

抗菌药物设计

RNA聚合酶抑制剂

Squaramides constitute a novel class of RNA polymerase inhibitors of which genetic evidence and computational modeling previously have suggested an inhibitory mechanism mediated by binding to the RNA

NIAID Data Ecosystem100

Kinetic parameters of WT and Δ-loop deletion mutant M. tuberculosis dUTPase enzymes and dissociation constants of dUTPase-dUPNPP complexes.

动力学分析

结核分枝杆菌药物靶点

Kinetic parameters of WT and Δ-loop deletion mutant M. tuberculosis dUTPase enzymes and dissociation constants of dUTPase-dUPNPP complexes.

Figshare2015-12-02 更新40

Crystal structure of CYP142 from Mycobacterium tuberculosis in complex with a fragment

蛋白质晶体

结核分枝杆菌药物靶点

Crystal structure of CYP142 from Mycobacterium tuberculosis in complex with a fragment Descriptor: (3-phenyl-1,2,4-oxadiazol-5-yl)methanamine, BROMIDE ION, CHLORIDE ION, ... Authors: Snee, M, Katariya

Protein Data Bank Japan2024-02-07 更新10

EthR2 in complex with SMARt-420 compound

结核分枝杆菌药物靶点

蛋白质-小分子复合物结构

EthR2 in complex with SMARt-420 compound Descriptor: 4,4,4-trifluoro-1-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)butan-1-one, Probable transcriptional regulatory protein Authors: Wohlkonig, A,

Protein Data Bank Japan2024-01-17 更新60

Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a DSF fragment hit

结核分枝杆菌药物靶点

基于结构的药物设计

Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a DSF fragment hit

NIAID Data Ecosystem40